Epigenetics is Here to Stay
Abstract
(ISSN 2577-5790)
OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Publication Speed (median values for papers published in 2023): Submission to First Decision: 5.1 weeks; Submission to Acceptance: 17.0 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)
Special Issue
Epigenetic Mechanisms in Health and Disease
Submission Deadline: May 31, 2018 (Closed) Submit Now
Guest Editors
Stéphane Viville, PhD
Professor, LABORATOIRE DE DIAGNOSTIC GENETIQUE, UF3472 – Infertilité, Nouvel Hôpital Civil,
1 place de l’Hôpital, 67091 Strasbourg cedex, France
Research Interests: human genetics of infertility; male and female infertility; human gametogenesis; human infertility and epigenetics; embryonic stem cells
Marcel Mannens
Professor, Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Research Interests: genome diagnostics; epigenetics of disease; cardiogenetics
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (genetics@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.
Welcome your submission!
Publication
Epigenetics is Here to StayAbstract none |
Redirecting Fetal Programming: Evidence of Interventions that May Be A Tool for HealthAbstract Understanding the pathophysiology of disease can be an essential step to determining where and how to intervene for preventive or corrective health. Intrauterine growth restriction (IUGR) is a broad category of ailments described by low fetal weight and accompanying susceptibility to adult onset of chronic disease through fetal programming [...] |
Genetic and Epigenetic Regulation of Telomere Length: Current Findings, Methodological Limitations and Possibilities for Future Studiesby
Taylor Lawrence
and
Therese M. Murphy
Abstract Telomeres are TTAGGG repeats located at the end of chromosomes that maintain DNA stability. Telomere length (TL) has been widely implicated as a marker of biological age, and is associated with several human diseases, including depression, cardiovascular disease and cancer. Twin studies and cohort studies estimate heritability of TL between [...] |
Distinct Mechanisms of Alterations in DNA Methylation/Demethylation Leading to Myelodysplastic Syndromes/Acute Myeloid Leukemia and Chronic Lymphocytic Leukemiaby
Cristina Bagacean
,
Anne Bordron
,
Tempescul Adrian
,
Jean Christophe Ianotto
,
Gaelle Guillerm
,
Wesley H Brooks
,
Marie-Anne Couturier
,
Mihnea Zdrenghea
,
Christian Berthou
and
Yves Renaudineau
Abstract Myelodysplastic syndromes (MDS) represent malignant myeloid disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). AML is a highly heterogeneous disease characterized by the presence of large chromosomal translocations, gene fusions as well as mutations [...] |
Evaluation of Classical Statistical Methods for Analyzing BS-Seq Databy
Shili Lin
and
Hengrui Luo
Abstract DNA methylation is an epigenetic mark that is not only important in normal cell development, but also plays a significant role in human health and diseases. As such, studies of DNA methylation to understand its precise role in disease etiology and its potential as disease biomarkers have been actively pursued. One key issue in analyzing DNA [...] |
Epigenetics and Infectious Disease: State-of-the-Art and Perspectives in New Generation TherapiesAbstract Epigenetics and Infectious Disease, State of the Art and Perspectives in New Generation Therapies |
Epigenetic Regulation by Androgen Receptor in Prostate CancerAbstract Prostate cancer is the most commonly diagnosed cancer in men all over the world. Androgen receptor (AR) functions as a nuclear receptor to facilitate ligand-dependent transcriptional activation in the nucleus. Advanced prostate cancer is treated with androgen deprivation therapy (ADT) because androgen and AR signaling drive the prostate tumor [...] |
The Induction of Histone H3K4 Methylation on the SI Gene Correlates with SI mRNA Levels in Enterocyte-Like Caco-2 CellsAbstract Background: Chromodomain-helicase-DNA-binding protein (CHD) 1 is Histone H3 lysine 4 (K4) methylation is thought to be important for the transcriptional activation of genes during differentiation.
Methods: mRNA and histone modification around SI gene in a small intestinal cell line Caco-2 during the differentiation were determined by qRT [...] |
Evaluation of Recent Statistical Methods for Detecting Differential Methylation Using BS-seq DataAbstract Whole genome profiling of differential DNA methylation between diseased and normal samples has significant implications in research to understand the role of epigenetic regulations of cells. In recent years, the development of bisulfite sequencing (BS-seq) based molecular technology has enabled the measurement of DNA methylation at a nucleotid [...] |
Current Evidence on the Role of Epigenetic Mechanisms in Migraine: The Way Forward to Precision MedicineAbstract This review explores current evidence to demonstrate that epigenetic processes contribute in migraine pathogenesis. Both basic experimental data and clinical findings will be presented and significant findings will be highlighted and discussed. Current challenges and unmet needs will also be listed. |
Deciphering the Epigenetic Landscape of Suicidal Behaviour: A Review of Current Findings, Caveats and Future DirectionsAbstract Suicide is the second leading cause of death globally among young people and the tenth leading cause of death across all ages. Approximately 800,000 people die by suicide every year representing a significant global health burden. Despite this burden, the molecular pathology of suicide remains poorly understood. A number of recent studies [...] |
Histone O-GlcNAcylation and Potential Biological FunctionsAbstract Histone modifications play an important role in the control of all DNA-based processes by altering the structure and function of chromatin. An O-linked N-acetylglucosamine (O-GlcNAc) modification is a type of post-translational modification of proteins, and gets attached to serine (Ser)/threonine (Thr) residues under the control of a sole [...] |
Epigenetics of IgA Nephropathy: A Brief ReviewAbstract Immunoglobin A Nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Its development is characterized by the deposition of immune complexes that consist of abnormally galactozylated IgA1 molecules and IgG or IgA autoantibodies in the mesangium and the subsequent induction of renal injury. Recent research has shed light [...] |
Uniparental Disomy and Imprinting DisordersAbstract Uniparental disomy (UPD), the inheritance of both homologues of a chromosome from only one parent, has been reported for nearly all human chromosomes. Depending on its mode of formation and time of occurrence, UPD can be present in all cells of an organism, or restricted to some cell lines as a mosaic UPD. Though its general frequency is unkno [...] |
New Insights into the Epigenetic Activities of Natural Compoundsby
Melita Vidakovic
,
Jessica Marinello
,
Maija Lahtela-Kakkonen
,
Daumantas Matulis
,
Vaida Linkuvienė
,
Benoît Y. Michel
,
Ruta Navakauskiene
,
Michael S. Christodoulou
,
Danielle Passarella
,
Saulius Klimasauskas
,
Christophe Blanquart
,
Muriel Cuendet
,
Judit Ovadi
,
Stéphane Poulain
,
Fabien Fontaine-Vive
,
Alain Burger
and
Nadine Martinet
Abstract Background: With their varied pharmacophores, natural products are interesting tools to open the drug discovery pipeline. Several plant secondary metabolites belong to our diet and have conflictual documented epigenetic activities which need clarification.
Methods: Seventy-one different natural products plus 17 controls were assembled for [...] |
Runs of Homozygosity and Epigenetic Deregulation of Genomic ImprintingAbstract Runs of homozygosity (ROH) are uninterrupted continuous regions within the genome exhibiting allelic homozygosity (identical alleles are inherited from each parent). Genome-wide analyses consistently evidence that megabase-scale ROH are ubiquitous in humans reflecting individual demographic history. The number and length of ROH increasingl [...] |
Epigenetic Symmetry of DLGAP2: Pre-Implantation Maternal Methylation Switches to a Random Monoallelic Profile in Somatic Tissuesby
Ana Monteagudo-Sánchez
,
Marta Sánchez-Delgado
,
Sonia Guara Ciurana
,
Jose Medrano
,
Maria Eugenia Poo-Llanillo
,
Miho Ishida
,
Gudrun E. Moore
,
Isabel Iglesias-Platas
,
Carlos Simón
and
David Monk
Abstract - Background
Symmetric DNA methylation profiles of autosomal genes is associated with equal expression from both alleles. Genes with an allelic imbalance or monoallelic expression are associated with discrete intervals of allele-specific methylation (ASM), as highlighted by genomic imprinting, X-chromosome inactivation and genotype-driven [...] |
Non-Coding RNAs in Cutaneous Melanoma Development, Progression and Disseminationby
Virginie Vignard
and
Delphine Fradin
Abstract Melanoma is a highly aggressive skin cancer with high incidence worldwide. There are growing evidences that aberrantly expressed non-coding RNAs (ncRNAs) play a role in the development, progression and dissemination of melanoma tumor cells. Among the many types of ncRNAs, we will describe in this review, the function of micro- and long non [...] |
Current Understanding of DNA Methylation and Age-related Diseaseby
Eunise M. Aquino
,
Miles C. Benton
,
Larisa M. Haupt
,
Heidi G. Sutherland
,
Lyn R. Griffiths
and
Rodney A. Lea
Abstract DNA methylation involves the covalent transfer of a methyl group to the C-5 position of the cytosine ring on a DNA strand which can affect gene transcription. DNA methylation is both heritable and modifiable. In recent years, epigenome-wide association studies using high-throughput technologies have associated variation in DNA methylation [...] |
The Role of Epigenetics in Developmental Programming and the Developmental Origins of Health and DiseaseAbstract A number of epidemiological studies have suggested that environmental stresses, such as malnutrition during the fetal period, can induce development of metabolic disorders, such as obesity, type 2 diabetes and hypertension, and psychiatric disorders in later life. This theory is known as the Developmental Origins of Health and Disease (DOHaD [...] |
2023 | ||
CiteScore | SJR | SNIP |
0.4 | 0.160 | 0.093 |
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