by Wasim A. Dar

Received: 03 September 2018;  Published: 29 September 2018;  doi: 10.21926/obm.transplant.1803021

liver transplantation

by Ashley Rosenberg  , Gilles Dongmo  , Pallavi Yadav  , Nathaniel Lee  and Kunal Yadav

Received: 13 August 2018;  Published: 21 September 2018;  doi: 10.21926/obm.transplant.1803020

Even though renal ectopia is common, there have been very few reports of these kidneys being used for transplantation. The concerns with using such kidneys are subnormal function, ureteral anomalies and complications and anomalous arterial supply which makes arterial reconstruction challenging. Majority of reports are for use in living donor transplantation where good preoperative imaging is available. There is very scant literature reporting use of ectopic pelvic kidneys from deceased donors. We report a case of a [...]

by Dayu Lv  , Jose Garcia-Tirado  and Chiara Fabris

Received: 17 May 2018;  Published: 11 September 2018;  doi: 10.21926/obm.transplant.1803019

Human pancreatic islet transplantation is a minimally-invasive procedure that is gaining recognition for the treatment of type 1 diabetes (T1D). Selected patients with unstable T1D, hypoglycemia unawareness, history of severe hypoglycemia, and glycemic lability, not successfully stabilized with intensive insulin treatment, can be offered this alternative therapy that has been shown to provide long-term glycemic control with near-normalization of hemoglobin A1c in the absence of severe hypoglycemia. Today, downsides [...]

by Rene J. Duquesnoy

Received: 11 July 2018;  Published: 05 September 2018;  doi: 10.21926/obm.transplant.1803018

The Holy Grail to Clinical Transplant Tolerance is Paved with HLA Epitopes

by Sean A. Hebert  , Aleksandra M. DeGolovine  , Karen J. Vigil  , Sonal Bhatnagar  , Cynthia S. Bell  and Rita D. Swinford

Received: 30 June 2018;  Published: 14 August 2018;  doi: 10.21926/obm.transplant.1803017

Background: Human Papilloma virus (HPV) infections are an increasingly concerning etiology for post-transplantation viral-related malignancies. The nonavalent HPV vaccine (Gardasil 9) affords transplant recipients the best opportunity for malignancy prevention, but remains underutilized. Not previously reported for solid organ transplant recipients, we studied influential factors for HPV vaccine non-initiation. Methods: This survey, conducted from May to December 2017, examined influential factors for HPV vaccine [...]

by Masahiro Sato  , Emi Inada  , Shingo Nakamura  and Issei Saitoh

Received: 28 March 2018;  Published: 02 August 2018;  doi: 10.21926/obm.transplant.1803016

(1) Background: Transplantation of isolated islets is one of the most powerful approaches to cure insulin-dependent (type I) diabetes mellitus (IDDM). Currently, the most widely used transplantation strategy is percutaneous perfusion into the liver via the portal vein. However, this approach has several drawbacks and is often limited by the large number of islets required and hypoxic damage to the grafts. (2) Methods: In this article, we posit intrapancreatic parenchymal cell transplantation (IPPCT) as a promising [...]

by Christine M. Bojanowski  , Ian Britton  and Kamyar Afshar

Received: 18 April 2018;  Published: 16 July 2018;  doi: 10.21926/obm.transplant.1803015

Here we present a case of a lung transplant recipient with alpha 1-antitrypsin deficiency as well as conducted a retrospective review of the United Network for Organ Sharing (UNOS) database from 1990 – 2016 specifically grouping patients with alpha-1 antitrypsin deficiency (A1ATD) and chronic obstructive pulmonary disease (COPD).

by Khawla F. Ali  , Vicente T. San Martin  , Tyler Stevens  , Matthew Walsh  , Rita Bottino  , Massimo Trucco  and Betul Hatipoglu

Received: 29 March 2018;  Published: 02 July 2018;  doi: 10.21926/obm.transplant.1803014

Total pancreatectomy (TP) is increasingly being utilized for definitive treatment in patients with debilitating chronic pancreatitis (CP). In an effort to prevent surgical diabetes, the procedure can be performed in conjunction with transplantation of islets of Langerhans recovered from the patients’ own resected pancreas (autologous islet transplantation, AIT). Given that patients undergoing TP and AIT are traditionally assumed not to be at risk for the development of beta-cell autoimmunity, it is possible that th [...]

by Yoshitaro Shindo  and Mazhar A. Kanak

Received: 29 March 2018;  Published: 22 June 2018;  doi: 10.21926/obm.transplant.1802013

Islet cell transplantation is a developing treatment for patients suffering from severe Type-1 diabetes. The long-term insulin independence after islet cell transplantation has been difficult to achieve, and this has been linked to several factors. One of the major cause of poor long-term outcome is inflammation surrounding the islets. Inflammation in islets is caused art several stages, donor induced, during organ preservation, islet isolation stress, peri-transplant inflammation or instant blood mediated inflamma [...]

by Victoria Gómez-Dos-Santos  , Vital Hevia-Palacios  , Edurne Ramos-Muñoz  , María Laura García-Bermejo  , Esperanza Macarena Rodríguez-Serrano  , Ana Saiz-González  , Jose Manuel Del Rey-Sánchez  and Francisco Javier Burgos-Revilla

Received: 22 March 2018;  Published: 21 June 2018;  doi: 10.21926/obm.transplant.1802012

Background: Extended criteria donors and donation after cardiac death donors provide organs which tend to be more sensitive to the stress of preservation. There is a lack of evidence about the potential role of oxygen in preservation techniques, and literature comparing oxygenated and non-oxygenated techniques is very limited. The aim of the study was to compare HMP with oxygen versus HMP without oxygen in a pig model of kidney auto-transplantation (KT) reproducing conditions of DCD. We have also set up miRNAs expr [...]